Spermatogonia Differentiation Requires Retinoic Acid Receptor γ

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Spermatogonia differentiation requires retinoic acid receptor γ.

Vitamin A is instrumental to mammalian reproduction. Its metabolite, retinoic acid (RA), acts in a hormone-like manner through binding to and activating three nuclear receptor isotypes, RA receptor (RAR)α (RARA), RARβ, and RARγ (RARG). Here, we show that 1) RARG is expressed by A aligned (A(al)) spermatogonia, as well as during the transition from A(al) to A(1) spermatogonia, which is known to ...

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Retinoic Acid Determines the Fate of Spermatogonia

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Retinoids, such as all-traneretinoic acid and 9-cisretinoic acid, are naturally occurring ligands of the nuclear retinoic acid receptors (RARs). In concert with binding of ligand, these receptors form heterodimers with the retinoic X receptor (RXR) and transactivate RAR/RXR-responsive genes. Retinoids can differentiate leukemic cell lines in vitro and induce clinically complete remissions in pa...

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retinoic acid determines the fate of spermatogonia

in this review, we aim to examine the effect of extrinsic and intrinsic factors on spermatogenesis process taking into account a complex signaling pathway. primarily, it is suggested that retinoic acid (ra) has a vital function in spermatogenesis process and it is considered to be essential for completion of spermatogonia into mature spermatozoa. in the present review, the key effects of retino...

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ژورنال

عنوان ژورنال: Endocrinology

سال: 2012

ISSN: 0013-7227,1945-7170

DOI: 10.1210/en.2011-1102